The Lady Hawks fell to 7-8 on the year after falling to H.W. Byers, 58-57 on Homecoming.
Byers held a four point lead after the first, and outscored the Lady Hawks throughout the first half to take a 43-30 lead to the half.
Myrtle came back in the third, outscoring Byers 20-6, and both defenses stepped up in the final frame, with Byers holding on for the divisional win.
Halle Knowles led Myrtle with 16 points. Keanna Cox made her return for Myrtle scoring 12, while Aspriona Gilbert was held to only 10 points.